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Paper-and-pencil methods of the early ethologists have largely been replaced by laptop computer and PDA-based event-recording sildenafil prescription uk systems. Basic methods of ethology—the study of animal behavior in natural settings, pioneered by the Nobel laureates Konrad Lorenz, Niko Tinbergen, and Karl von Frisch—involve direct observation of behavior, including descriptive and quantitative methods for coding and recording behavioral events. Several software packages now are available that are optimized for coding behavior in real time or from video recordings, using focal subject, onezero, instantaneous, or other structured sampling techniques (Lehner, 1993). We can expect that applications in real-world environments also will expand, as technologies for monitoring animals in laboratory environments improve. Indeed, most modern neuroscience laboratories involve some form of automated recording of behaviorally relevant data from external devices or physiological sensors placed on or implanted within the animal.