• RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    The choice of stem cell in human clinical trials reflects, in part, the investigator‟s belief on the mechanism of action. In a rat model of severe chronic liver injury, MSC failed to reduce fibrosis and improve liver function [222]. Many of the initial studies suggested that HSCs were the predominant cell type involved [223], but more recently in vitro and in vivo experiments have supported transdifferentiation of MSCs into hepatocytes [65, 214, 205]. If investigator believes plasticity is the major mechanism, then there is literature supporting both HSCs and MSCs, although it is more compelling for MSCs.

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