• RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    1995 Flint M, maturitas 20:261–316. Reward or punishment?.

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    Much work in the addiction field has shown that activation of CREB in the nucleus accumbens is a consequence of chronic sildenafil masticable mexico exposure to opiates and MOLECULAR HYPOTHESIS OF ADDICTION 399 FIGURE 10.18 Regulation of gene expression by drugs of abuse (Nestler, 2002). Which makes the gene accessible to a basal transcription complex, transcription requires the unwinding of a nucleosome. CREB regulates the transcription of genes that contain a cAMP response element site within the regulatory regions and can be found ubiquitously in genes expressed in the central nervous system such as those encoding neuropeptides, synthetic enzymes for neurotransmitters, signaling proteins, and other transcription factors. CREB can be phosphorylated by not only protein kinase A but also by protein kinases regulated by growth factors putting it at a point of convergence for several intracellular messenger pathways that can regulate the expression of genes (Nestler, 1999) (Fig.

    8.15). 10.20). ‘The rate of expression of a particular gene is controlled by its location within nucleosomes and by the activity of the transcriptional machinery (Carey and Smale, 1999). A nucleosome is a tightly wound span of DNA that is bound to histones and other nuclear proteins.

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    Endoscopic treatment has been shown to be successful in 95% of cases. This can establish a diagnosis in 54% to 90% of cases. Ileocolonoscopy, following a rapid polyethylene glycol bowel purge, is the diagnostic method of choice for LGIB.

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