Type I AIH can occur in all age groups, but most patients are sildenafil dosage uk young and predominantly female (50%). Many patients have clinical (arthralgias [40%]) and laboratory manifestations that may resemble systemic lupus erythematosus (SLE). AUTOIMMUNE AND OTHER LIVER DISEASES 8. What is lupoid hepatitis?.
Lupoid hepatitis is now called type I (classic) autoimmune hepatitis (AIH). Patients commonly have positive ANAs, antibodies against smooth muscle antigen (80%) frequently with specificity against F1 actin, and occasionally lupus erythematosus (LE) cells.
Fluconazole Asymptomatic elevations sildenafil dosage uk of hepatic enzymes may occur during ﬂuconazole therapy. Biochemical abnormalities pointed to a mixed cytolytic-cholestatic liver injury or a prominent cholestatic pattern. In some studies involving immunocompromised patients, the reported incidence was higher (288). Fluconazole may give rise to symptomatic hepatotoxicity only rarely. The underlying disease or concomitant medications make causal relationship uncertain in this kind of population, however.
Nonfatal hepatotoxicity has been described in eight case reports. They are mild and transient and occur in 6% of patients (322). Five of these patients were HIV-positive and had received ﬂuconazole for a few days to 5 months.
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