This holds true also rx sildenafil citrate in patients suffering from very severe acute liver disease with the potential for fulminant hepatic failure. Supportive treatments may be needed in case of severe cholestasis or hepatocellular insufﬁciency. Therapy with corticosteroids may be used in patients with evident hypersensitivity but controlled trials have not proved the efﬁcacy of such treatment. Management of drug-induced hepatotoxicity is usually conﬁned to the discontinuation of the causative agent, with careful observation of the patient to make sure the expected improvement begins to occur within 4 weeks.
Rarely, liver transplantation may appear as the sole therapeutic tool for some cases of fulminant hepatic failure (9,296).
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Usefulness of measurement of Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein as a marker of prognosis and recurrence of small hepatocellular carcinoma. Am J Gastroenterol.
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