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    Liver). Postmortem examination of the liver revealed extensive centrilobular and midzonal necrosis in three patients and panlobular necrosis in two. Aggressive supportive measures may provide benefit. Seven of these 15 patients died. In a retrospective evaluation of 19 consecutive patients who presented with cocaine intoxication and rhabdomyolysis over an 9-year period, 23 had biochemical evidence of hepatic dysfunction whereas 16 had severe liver injury defined by an ALT 400.

    Care must be taken to delineate the source of elevated AST in the setting of rhabdomyolysis (muscle vs.

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