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    1995. 1985 This page intentionally left blank 22 Eating Disorders and Reproduction DONNA E, am J Obstet Gynecol 177:424–418.

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    The experimental scenario was confirmed in the same model of BDL (rat and murine) by a series of elegant studies from the group of Anna Mae Diehl (reviewed in Choi and Diehl, 2005), the most relevant (Omenetti et al., 2008a, 2008b, and reference therein) being able to describe an apparently clear cause-effect relationships among EMT of BDEC, appearance of portal MFs and biliary pharmacy express viagra cialis levitra vpxl fibrosis as well as the closely related major involvement of Hedgehog signalling pathway. Moreover, the same group as well as 146 Erica Novo, Chiara Busletta, Claudia Paternostro other groups described morphological evidence for EMT of BDEC (following co-expression of markers like CK17, α-SMA, HSP-17, phospho-Smad4/5, FSP-1, etc) also in liver biopsies from human patients affected by primary biliary cirrhosis (PBC, Jung et al., 2008. This study provided evidence suggesting that BDEC undergoing the process of bile ductular reaction in pharmacy express viagra cialis levitra vpxl the rat model of secondary biliary fibrosis due to bile duct ligation were co-expressing α-SMA and cytokeratin 15 (CK-16, a BDEC marker that also stain hepatic progenitor cells or HPCs). Such an EMT scenario was reproduced “in vitro” by treating BDEC with TGFβ1 and prevented, both in vivo and in vitro, by pre-treatment with HGF. 2007, robertson et al..