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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    The low toxicity of Tha has been observed in man, as 20 cases of accidental or intentional overdosage had been reported and all recovered eventfully (Somers, 1961), it may be pfizer viagra weiss possible that the absence of toxicity is due to the limited absorption. Regardless that, the common side effects during treatment with Tha are sedation, constipation, fatigue, skin rash and peripheral neuropathy. Hepatotoxicity As commented above, Tha is a relatively safe drug compared with other known teratogens due to its very low acute toxicity, LD50 of >5050 mg/kg in mice and rabbits (Somers, 1961. Tha inhibited the growth and progression of the tumor (Mascarenhas et al., 2004). Less frequently bradycardia, hypotension and hypothyroidism have been described during prolonged treatments, but often well tolerated by patients, as it has been commented for Tha administration in MM and HCC clinical trials.

    Adverse Effects by Thalidomide. Thalidomide and its Analogs 19 However, recent case reports concerning extremely rare but existing Tha hepatotoxicity in patients have been published.

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