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    And by Franceschini patent expiration date of viagra & Boas, 2002), typically as increases in the transparency of active cortical areas. As shown later, this is exactly the result we typically obtain in our studies. It should further be noted that these predictions are related to TR measurements.

    In fact, cortical excitation should be associated with an increase in the average photon time of flight (because, on average, the photons penetrate deeper into the tissue), and cortical inhibition should be associated with a reduction in the average time of flight (because, on average, the photons penetrate less into the tissue). Because at shallower depths light propagation may not follow a diffusive regime, it should be noted that these predictions only hold for situations in which the activated area is at least 5–10 mm deep. In fact, fast optical effects can also be recorded with CW methods (as demonstrated by Steinbrink et al., 1996.

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