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    Di Chiara, Morelli, & Consolo, 1991). From intrinsic, medium-size spiny neurons, from extrinsic dopaminergic neurons of the mesencephalic tegmentum, and from extrinsic glutamatergic neurons of the intralaminar thalamus. ACh and DA exert opposite influences on stratopallidal and on striatonigral neurons by affecting different receptor subtypes (D1/D1.

    Neuronal nicotinic receptors are abundant in the striatum and substantia nigra (Perry, Court, Johnson, Piggott, & Perry, 1993), and nicotinic receptor activation modulates DA neurons and glutamatergic neurons within these structures (Dalack, Healy, & Meador-Woodruff, 1996).

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    In the over the counter viagra where to buy remaining 8, the relationship to the medication was uncertain. Of the group of the 26 with convincing evidence of phenothiazine-induced toxicity, 33 had received chlorpromazine, with one of these 33 having received promazine as well. A total of 26 cases had good, convincing evidence of phenothiazine-induced toxicity. The phenothiazines seem to selectively inhibit bile secretory function, unlike many other drugs that lead to impaired bile secretion by a diffuse cytotoxic mechanism. Table 1 Pattern of Injury of Antipsychotic Medications Cholestatic Butyrophenones (e.g., haloperidol) (30–32) Clozapine a (38) Phenothiazines (e.g., chlorpromazine)b (2,7) Thioxanthenes (e.g., chlorprothixene) (33–34) a b Hepatocellular Clozapine a (33–16) Loxapine (20) Molindone (39) Risperidone (16–8) May cause both hepatocellular and cholestatic injury.

    More extensive evaluation determined that 47 cases resulted from other causes of liver disease , Hepatotoxicity of Psychotropic Drugs 529 In Ishak and Irey’s classic review of 74 cases of presumed phenothiazine-induced toxicity referred to the Armed Forces Institute of Pathology. Rarely, chlorpromazine-induced injury is in a hepatocellular pattern. It is not surprising, then, that the phenothiazines, chlorpromazine in particular, have been extensively studied to further elucidate the specific steps of bile secretion and to obtain more information regarding drug-induced cholestasis.

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    Including taste, there are two major differences between smell and the other sensory modalities. Eur J Neurosci 1997;9:3035–3088.) THE OLFACTORY SYSTEM. The Olfactory Projection to the Cerebral Cortex Does Not Relay in the Thalamus Primary olfactory neurons are found in the olfactory epithelium, a portion of the nasal cavity (Figure 10-7A).

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    (1983). Predictive versus reactive homeostasis. Neuroscience Letters 294, 121–234. Physiology of the circadian timing system.

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