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    Friston, Phillips, Chawla, & Buchel, 2000. Traditionally, most functional imaging studies have utilized univariate analyses, permitting only the indepen- 212 F U NCT I O NA L A N D S T R U C T U R A L I M A G I N G A P P R O A C H E S dent assessment of activity within each brain region in isolation.

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    An alternative site for processing may occur within or close to the cell membrane, whilst a limited degree of processing may occur in these cells in intracellular sites. Dendritic cells) exhibit poor phagocytic activity. Such internalization mechanisms help to explain how antigen gains access to intracellular processing compartments (Figure 5.1).

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