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    Molecular biology is of special importance to the clinical hematologist, as leukemias and lymphomas are clonal neoplasms and can be detected by DNA analysis if a genetic marker lesion is known. Chapter 2 / Molecular Biology and Cytokines 19 5 Molecular Biology and Cytokines Reinhold Munker, MD and Amanda Sun, MD, PhD CONTENTS INTRODUCTION RECOMBINANT DNA TECHNOLOGY CLONALITY OF TUMORS DIAGNOSTIC APPLICATIONS OF MOLECULAR BIOLOGY AND GENE THERAPY CYTOKINES SUGGESTED READING 1. The discovery of DNA sequences in normal cells that are homologous to RNA viruses led to the description of oncogenes.

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