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    Brain-Machine Interactions for Understanding Neural Computation Some investigators have used the closed-loop interaction between nerve cells and external devices as a means to study neural information processing (Kositsky, Karniel, online viagra sales canada Alford, Fleming, & Mussa-Ivaldi, 1999. Potter, 1997. have grown cell cultures from chick embryos over microelectrode arrays and have succeeded inducing plastic changes by applying drugs that acted on glutamate receptors.

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  • 1.29). Thus, the reinforcing value of drugs may change with dependence. Data are expressed as means ± SEM.

    Access to heroin for 24 h via intravenous self-administration with continuous concomitant access to food and water via a nosepoke response led to a more rapid escalation of heroin intake than previous models and even more rapid development of dependence. Animals showed signs of dependence as early as 3 days into continuous access as measured by changes in the pattern and distribution of heroin and food intake. In addition, animals with 24-h access to heroin self-administration that have escalated intake show increases in heroin self-administration to very low doses of naloxone and decreases in heroin self-administration to administration of buprenorphine, validating pharmacologically this procedure as a measure of dependence (Fig.

    ANIMAL MODELS OF DRUG ADDICTION and active prolonged intravenous self-administration led to the exploration of an unlimited-access model of intravenous heroin self-administration. [Reproduced with permission from Roberts et al., 1997.] 56 4.

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    In. Las obesidades, Cuadernos de medicina estetica. Vague J. Marseille, France, 1990, n.

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