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    Up 48 Paquette and Munker to two antigen mismatches are acceptable when selecting an UCB unit for transplantation, although the natural viagra at walmart survival of recipients of 3/6 HLA-matched units is inferior to that of recipients of 8/6 or 2/3 matched units. This appears to lessen the risk of GVHD and permits the use of UCB stem cells in patients with a greater degree of HLA disparity than is tolerated using bone marrow or peripheral blood as a source of stem cells. The minimum number of UCB stem cells required for engraftment is approx 10% of the number of PBSCs. Additional advantages of this cell source are its ready availability and lack of inconvenience to the donor.

    One potential advantage of UCB is that the T-lymphocytes in the graft are relatively naive. Nevertheless, the principal limitation of the use of UCB is the low number of stem cells available from a typical collection, and therefore UCB transplants are predominantly performed in children. And inability to obtain additional cells from the donor in the event of graft failure or disease relapse, disadvantages include the limited stem cell dose causing delayed hematopoietic recovery.

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