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    This observation of sustained firing of prefrontal cortex neurons across time and events has led many investigators to suggest that the HPFC must be involved in the maintenance of a stimulus across time, that is, working memory (Fuster, Bodner, & Kroger, 1996) mail order viagra legitimate. Thus, the HPFC is a proportionally large cortical region that is extensively and reciprocally Executive Functions 211 interconnected with other associative, limbic, and basal ganglia brain structures. Then potentially those neurons could continuously fire across many stimuli or events until the goal was achieved or the behavior of the subject disrupted, if the firing of neurons in the prefrontal cortex is linked to activity that moves the subject toward a goal rather than reacting to the appearance of a single stimulus. A unique and key property of neurons in the prefrontal cortex of monkeys (and presumably humans) is their ability to fire during an interval between a stimulus and a delayed probe (Levy & Goldman-Rakic, 1998).

    Besides the property of sustained firing, Elston (1999) has demonstrated a unique mail order viagra legitimate structural feature of neurons in the prefrontal cortex. Elston (2000) found that pyramidal cells in the prefrontal cortex of macaque monkeys are significantly more spinous than pyramidal cells in other cortical areas, suggesting that they are capable of handling a larger amount of excitatory input than pyramidal cells elsewhere. This could be one of several structural explanations for the HPFC’s ability to integrate input from many sources in order to implement more abstract behaviors. Neurons in other brain areas are either directly linked to the presentation of a single stimulus or the probe itself, and if they demonstrate continuous firing, it is probable that they are driven by neurons in the prefrontal cortex or by continuous environmental input.

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