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  • Smokers report the first cigarette of the day to be the most pleasurable (Russell, 1985), possibly because levitra results video of nicotine-induced activation of recovered nAChRs 374 7. Activation of these receptors also would cause dopamine release, thus contributing to the maintenance of cigarette smoking throughout the waking hours. Thus, the development and perpetuation of nicotine addiction may involve selfmedication to effectively control the number of functional nAChRs along pathways affected by nicotine (Dani and Heinemann, 1997.

    Receptor desensitization and recovery occurred at different rates, suggesting that within the ventral tegmental area, there are multiple types of nAChRs with different activation and desensitization profiles (Pidoplichko et al., 1998). Koob et al., 1997). Throughout the day, smokers maintain a steady blood nicotine level (Benowitz, 1997) and are exposed to nicotine concentrations which cause nAChR desensitization in the ventral tegmental area (Pidoplichko et al., 1993).

    NICOTINE in the ventral tegmental area, leading to greater dopamine release than later in the day. If different nAChRs in the ventral tegmental area have different sensitivities to nicotine, as suggested above, it may be that once a steady-state of nicotine is reached, periodic readministration of nicotine engages nAChRs only activated by high nicotine doses.

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