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    This supports the assertion that representations are stored in posterior sensory regions, and top-down signals from the PFC trigger the activation of these memory representations (Miyashita, 2000) levitra online with prescription. Ranganath, Johnson, & D’Esposito, 2000), these results establish a role of PFC-mediated top-down modulation in LTM. 1998, coupled with the results of lesion–behavior studies and functional neuroimaging studies (Lee et al.. Recent lesion–physiology studies in ro- Unifying Prefrontal Cortex Function 235 dents have also revealed the presence of modulatory PFC influences on the activity of hippocampal place cells (Kyd & Bilkey, 2004) and perirhinal neurons during a spatial DRT (Zironi, Iacovelli, Aicardi, Liu, & Bilkey, 2000). Combined lesion–ERP studies have provided evidence of PFC-dependent topdown enhancement of visual association cortex activity occurring in the first few hundred milliseconds of the visual processing for selectively attended stimuli , in humans.

    Moreover, electrophysiological alterations accompanying PFC lesions were associated with deficits in visual detection ability. Comparable findings of PFC-mediated ERP enhancement and performance dependence have been obtained during a selective attention auditory task. There is also evidence in humans that the PFC exhibits suppressive control over distant cortical regions.

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  • (2001). Reichlin, M. Neurology, 11, 695–751. Ribosomal P antibodies and CNS lupus. Lupus, 8, 946–958.

    Reina, S., Sterin-Borda, L., Orman, B., & Borda, E. (2005). Autoantibodies against cerebral muscarinic cholinoceptors in Sjogren syndrome.

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