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12], higher incidence was reported in series levitra mexico that included autopsied cases [9. Pathogenesis of HCC in HVD is not clear. Though most of the HCC in HVD occur in patients with LC, it can also occur in those with out cirrhosis [9, 13, 42, 13]. Anti-HBe positive with serum HBV DNA <2,000 IU/ml is considered inactive HBsAg carrier and ALT elevation or LC in these patient may be due to associated HVD , patient with HBsAg+ for > 2 months but is HBeAg negative.
Incidence and Pathogenesis of HCC in HVD The reported incidence of HCC in HVD varied from 4.2% to 37% [5-15, 22, 33, 30, 21]. It was 14% in 44 HVD patients with LC followed for 10.6 + 8 years . Over all incidence of HCC in HVD patients that have been followed for long term was 6%. Similarly LC in patient with chronic alcohol use of < 30 g/ day for <5 years or anti-HCV positive but HCV RNA negative may be due to associated HVD.