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They concluded that such responses depended on factors such as parasite load and the levitra jelly geographical origin of the leishmanial isolates but suggested that the three responses might be the outcome of a common immunological mechanism. Skin responses in laboratory models Experimental models of leishmaniasis are of course subject to greater control, and by selecting various host/ parasite relationships, a considerable spectrum of disease patterns can be reproduced. 1) elimination of parasites within intact macrophages that later evolved as epithelioid cells, 4) elimination of parasites as a result of macrophage lysis and 5) necrosis at levitra jelly the centre of a focal mass of macrophages. Immunocytochemical staining has revealed a predominance of helper over-suppressor T cells in both mucosal and cutaneous lesions, while granulomatous reactions have been recorded on occasion near ulcer surfaces, and hyperplasia of the epidermis is a prominent feature (Barral et al., 1988).
Ridley and Ridley (1980) identified three basic mechanisms of parasite elimination from histological analysis of human skin biopsies.