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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    Anti-HCV Liver biopsy High-risk patients only Prior excessive alcohol consumption Persistently abnormal baseline AST values Chronic hepatitis B or C infection ?, baseline or prior to MTX therapy Blood tests CBC BMP HBsAg.

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    Sequence analysis of the human MRP4 promoter showed a number of putative consensus binding sites for both ubiquitous and liver-enriched transcription factors, including activating protein AP1, SP1, HNF1, and HNF4β (Fig. Thus C/EBPβ likely has an important role in the transcriptional control of MRP5 gene expression, at least in HepG4 cells (181). From studies with various deletion constructs it appears that important elements are localized in the 521/ 278 region that controls expression in HepG4 cells.

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