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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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  • 16–28). The inflammation is usually composed of mononuclear cells. Cholestasis with Inflammation Cholestatic drug-induced liver cell injury may also be associated with a lobular inflammatory infiltrate (29) (Table 8, Figs. The adjacent parenchyma is devoid of inflammatory cells.

    Although in severe cases the features may be diffuse, cholestasis with inflammation is often enhanced in the perivenular zone. 268 Kanel Table 8 Cholestasis with Inflammation Alpha-methyldopa Acetaminophen Acetohexamide Allopurinol Aminoglutethimide Aminosalicylic acid Amitriptyline Amoxicillin-clavulanic acid Aprindine Atenolol Azathioprine Benoxaprophen Captopril Carbamazepine Carbarsone Carbimazole Carisoprodol Cefadroxil monohydrate Cefazolin sodium Chlorambucil Chlordiazepoxide Chlorothiazide Chlorpromazine Chlorpropamide Chlortetracycline Chlorthalidone Cimetidine Cisplatin Clarithromycin Clorazepate dipotassium Cyclosporine Dacarbazine Dantrolene sodium Diazepam Diclofenac Disopyramide phosphate Enalapril Erythromycin Ethchlorvynol Ethionamide Flucloxacillin Fluoxymesterone Fluphenazine Flurazepam hydrochloride Flutamide Glibenclamide Gold sodium thiomalate Griseofulvin Halogenated hydrocarbons Haloperidol Imipramine Indomethacin Iodipamide meglumine Isocarboxazid Isoniazid Ketoconazole Meprobamate 5-Mercaptopurine Naproxen Nicotinic acid Niacin Nifedipine Nitrofurantoin Nomifensine Oxacillin Oxaprozin Oxyphenisatin Papaverine hydrochloride Para-aminosalicylic acid Penicillamine Penicillin Perphenazine Phenobarbital Phenylbutazone Phenytoin Piperazine Piroxicam Pizotyline Polythiazide Prajmalium bitartrate Prochlorperazine Propoxyphene hydrochloride Quinethazone Ranitidine Rifampin Sulfasalazine Sulfonamides Sulindac Tamoxifen Thiabendazole Thiopental sodium Thioridazine Ticlopidine Tocainide Tolazamide Tolbutamide Total parenteral nutrition Toxic oil (rapeseed) Tranylcypromine sulfate Triazolam Trifluoperazine hydrochloride Trimethobenzamide hydrochloride Trimethoprim-sulfamethoxazole Tripelennamine Troleandomycin Valproic acid Verapamil Zimelidine duct obstruction, the portal duct changes may be subtle, and other parameters such as imaging studies may be most important in identifying the cause. The inflammation is usually mild with the cholestatic component more striking.

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