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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    18.  Histologically, how do you differentiate gastric antral vascular ectasia , portal hypertensive gastropathy, Dieulafoy lesion, and radiation injury?.

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    The early phase of acquisition of heroin selfadministration was accompanied by an increase in elated mood and a decrease in ‘somatic concern’. The later stages of acquisition were characterized by a profound shift toward increasing dysphoria, a notable rise in somatic concern, anxiety, depression, social isolation, and motor retardation. [Reproduced with permission from Marsch et al., 2000.] FIGURE 3.4 210 5.

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    The earliest changes are ultrastructural and include lysosomal and mitochondrial injury, endoplasmic reticulum hypertrophy, autophagic vacuole formation, and desmosomal injury. There is bile duct damage (43) and stellate cell (Ito cell, lipocyte, or fat-storing cell) hyperplasia (11,14). Alcohol abuse and other causes of liver injury could be identified in most cases, in those patients with more than mild fibrosis.

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