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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    And there is complete disequilibrium between illegal order cialis online polymorphisms that span the gene , two extended haplotypes cover the human tau gene. This suggests that the establishment of the two haplotypes was an ancient event, and that either recombination is suppressed in this region, or recombinant genes are selected against. What is striking is the severity of atrophy and its localization to the frontal or temporal lobe, or both, and less commonly to the parietal lobe.

    Neuropathology The appearance of the PiD brain is one of the most dramatic in all neuropathology (Figure 26.5). The more common haplotype (H1) is significantly overrepresented in patients with progressive supranuclear palsy (PSP) (Baker et al., 1997), but there is no difference between the tau H5 haplotype or H5/H1 genotype frequency in PiD cases when compared with control subjects, and no tau mutations have been found in pathologically typical cases of PiD (Morris, Baker, et al., 2003).

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