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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    Individuals with demyelination of frontal–subcortical homemade viagra alternative circuits in MS on MRI performed worse on tasks of conceptual reasoning abilities (Wisconsin Card Sorting Test) and had more perseverative errors than others without significant frontal involvement but with similar overall white matter burden (Arnett et al., 1994). Mendozzi, Pugnetti, Saccani, & Motta, 1990), including deficits in verbal fluency, conceptual reasoning, the Wisconsin Card Sorting Test, planning abilities, organizational skills, sustained attention, and set shifting (Fennell & Smith, 1989. Neuropsychological testing shows specific frontal lobe dysfunctioning in 33% of patients with MS (McIntosh-Michaelis et al., 1988. 1991), mendozzi et al.. SwirskySacchetti et al., 1991).

    Frontal white matter lesions are also correlated with apathy, diminished spontaneity of speech, executive dysfunction, and slowed information-processing speed (Comi et al., 1991. 1992b, corpus callosal atrophy on MRI and increased plaque volume correlate with the severity of cognitive impairment (Huber et al..

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    4.3.6. ANTIBODIES/COMBINED IMMUNO-CHEMOTHERAPY The monoclonal anti-CD16-antibody rituximab destroys lymphoma cells via complement- and antibody-mediated cellular cytotoxicity. However, no major myelotoxicity has been observed. However, consistent data on overall survival are still lacking, and late side effects (secondary malignancies) represent an inherent risk of this approach.

    Recent studies attempt to remove malignant cells with immunomagnetic purging or combine high-dose chemotherapy with in vivo purging. Younger patients with follicular lymphomas have an unfavorable long-term prognosis, despite the initial good response. Side effects of rituximab are mainly fever and a depletion of normal B-cells. Such an approach is myeloablative chemoconsolidation with subsequent autologous SCT and results in prolonged progression-free survival (>60% risk of relapse).

    Therefore, these patients are candidates for novel treatment strategies, especially if risk factors like B-symptoms or large lymph node masses are present.

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