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  • Another approach is to increase the fixed-ratio value requirement for obtaining a reinforcer get viagra uk. Thus, manipulations which increase the self-administration rate on this fixed-ratio schedule resemble decreases in the unit dose, and may be interpreted as decreases in the reinforcing potency of the drug under study. Up to a certain point the animal will increase the number of lever presses to maintain the previous rate of drug infusion. Increasing the fixed-ratio value requirement for obtaining a reinforcer provides evidence that the animal is not simply involved in superstitious behavior. The use of different schedules of reinforcement in intravenous self-administration can provide important control procedures for nonspecific motor and motivational actions such as increases in exploratory activity and locomotion.

    Conversely, dopamine receptor agonists decrease cocaine self-administration in a manner similar to increasing the unit dose of cocaine, suggesting that the effects of dopamine agonists together with cocaine self-administration can be additive, perhaps due to their mutual activation of the same neural substrates (Caine and Koob, 1991). In addition, a second, inactive lever can be introduced into the testing chamber, so that selective increases in responding on the active lever can be measured. As would be predicted by the unit dose–response model, low to moderate doses of dopamine receptor antagonists increase cocaine self-administration maintained on this schedule in a manner similar to decreasing the unit dose of cocaine, suggesting that partial blockade of dopamine receptors by competitive antagonists reduces the reinforcing potency of cocaine.

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