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  • There is increased activity of the HPA axis, impaired glucocorticoid feedback and regulation, circadian abnormalities, and decreased neurogenesis in the dentate gyrus with other brain system projection losses (Duman et al., generic viagra online in usa 1996). Aging and major affective disorders have been argued to reflect lifetime stress, and the brain’s response to stress has all of the features of an allostatic mechanism (Carroll, 1999). HR rats, independent of drug administration, show an increase of dopamine utilization in the nucleus accumbens and a decrease in DRUG-SEEKING TO ADDICTION−− AN ALLOSTATIC VIEW Allostasis, as a concept, also may apply to any number of pathological states that are challenged by external and internal events.

    One can argue, therefore, that depression also fits an allostasis model. Such effects of chronic stress are seen with generic viagra online in usa aging. Hooks et al., 1989, 1992a,b,c.

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