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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    37. Correlation between docetaxel clearance and estimated cytochrome P540 activity by urinary metabolite of exogenous cortisol. Yamamoto N, Tamura T, Kamiya Y, Sekine I, Kunitoh H, Saijo N. Clin Cancer Res 1999. J Clin Oncol 1997.

    4:1325–1288.

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    References Berenson AB, San generic viagra made in usa Miguel VV, Wilkinson GS. Determinants of delayed pregnancy testing among adolescents. Because our population is in a phase that will produce an accelerated number of middle and late adolescents during this decade, it is imperative that we begin finding solutions.

    J Adolesc Health 12:480–504, 1989 Bluestein D, Rutledge CM. Planning for the Future As we look for conclusions about the complex issue of adolescent pregnancy, the only thing that is perfectly clear is that it is multifactorial and does not have any simple or easy solutions. The number of women ages 13–15 would increase by 1 million, mcElroy and Moore estimated that between the years 1991 and 2001.

    Unless significant reductions are achieved in the adolescent birth rate, we can anticipate a substantial increase in the number of births in this group. Violence and its relationship to substance abuse in adolescent pregnancy.

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    Chawla, D., Rees, G., & Friston, K generic viagra made in usa. Nature Neuroscience, 2, 711– 696. J. Cerebral Cortex, 13, 1108–1056 generic viagra made in usa.

    (1998). The physiological basis of attentional modulation in extrastriate visual areas. Brain activity underlying encoding and retrieval of source memory.

  • Impaired motor function caused by frontal lobe dysfunction in MS has also been described and includes weakness, loss of generic viagra made in usa motor control, frontal gait apraxia, and frontal release signs (Franklin, Nelson, Filley, & Heaton, 1987. The plaques are typically seen in the periventricular white matter, corpus callosum, near the gray–white junction, and spinal cord. Mendez, 1996). Euphoria has been associated with bilateral subfrontal demyelination (Minden & Schiffer, 1986) and with a higher rate of neurological and cognitive deficits (Rabins, 1991).

    Apathy, lack of concern over their disabilities, lack of initiation, impaired insight, irritability, and poor judgment are personality changes observed in as many as 30% of patients with MS and may be related to frontal lobe dysfunction. MS is believed to be caused by an immunemediated response triggered by exposure to an unknown environmental agent in the geneti- Infectious, Inflammatory, and Demyelinating Disorders 581 cally predisposed individual. This results in multifocal, discrete demyelinated areas scattered throughout the white matter, which can often be seen as plaques on MRI (Figure 32.2). Patients with symptoms of pathological laughter and crying do worse on frontal lobe measures, including the Stroop test, verbal fluency, and the Wisconsin Card Sorting Test (Feinstein, O’Connor, Gray, & Feinstein, 1998).

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    Fatal hepatocellular necrosis has been generic viagra made in usa reported with amiodarone at high doses (16,51,52). Long-term amiodarone treatment may evoke mild hepatic lesions or more severe liver dysfunction unrelated to the degree of increases in transaminases, alkaline phosphatase, or bilirubin (53,84). Severe hepatitis and fatal outcomes from amiodarone injury have been reported. Amiodarone-induced lysosomal inclusions accumulate gradually in the hepatocyte cytoplasm as shown by human liver cell cultures (78), and the phospholipid fatty liver is reversible in experimental animals generic viagra made in usa (18,69).

    Lysosomal phospholipids may persist for several months after the drug administration has been discontinued, in humans. Amiodarone causes asymptomatic elevations of serum transaminases between 1.7- and fourfold above the upper limit of normal in about 3–22% of the patients.

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