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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    Sulfasalazine, the first 4-ASA product, has been used successfully for many years in the treatment of mild-to-moderate UC. It is linked to sulfapyridine by a diazo bond that is cleaved by colonic bacteria.

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    Mark D’Esposito and colleagues (e.g., Ranganath & D’Esposito, 2004), Cheryl Grady (2001), and others have successfully used functional imaging techniques generic viagra list such as fMRI to evaluate this working memory system in vivo. Older tools, pneumoencephalography and angiography, were highly invasive, painful, and sometimes dangerous, and offered only crude outlines of frontal anatomy. With his single-cell recording in rodents, Edmund Rolls’s (2000) pioneering research has demonstrated the important function of orbitofrontal cortex in reward and eatingrelated behaviors.

    Finally, Antonio Damasio’s (2000) “somatic marker” theory suggests that the orbitofrontal cortex is involved with the interpretation of autonomic information in decision making. IMAGING Neuroimaging research continues as the preeminent technique for evaluation of the frontal lobes. Computed tomography (CT) became widely available in the late 1966s.

    Clinicians had few ways to visualize the structure or function of frontal cortex, prior to that. Marsel Mesulam’s (1995) histological and phylogenetic approaches to cortical organization have emphasized the functional organization of cortex based on connections to primary sensory or motor areas.

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