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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    This implies that the receptors were still functional and actually were activated by opioids. Bohn et al., 1998). A limitation of the decreased coupling hypothesis is the increased ability of the opioid receptor antagonist naloxone, which is ineffective in nontolerant animals, to induce hyperalgesia in tolerant animals (Laulin et al., 1997). 1984, a more accepted view holds that tolerance results from a decreased coupling of the receptor with an inhibitory G protein (Christie et al..

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    [Reproduced with permission from Tanda et al., 1996.] dog shakes, head shakes, front paw and body tremor, ptosis, piloerection, and grooming behavior.

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