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    Genotypes A and B appear to be especially susceptible to interferon therapy. The addition of an appropriate second agent may be considered, when monotherapy has resulted in the appearance of drug-resistant hepatitis B virus. For instance, after lamivudine resistance occurs, adefovir may be added for salvage therapy. Interferons are associated with neuropsychiatric side effects, bone marrow depression, activation of autoimmune syndromes, hyperthyroidism or hypothyroidism, and a flulike illness following the administration of the drug, among many others.

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