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    First, in peripheral capillaries, endothelial female viagra for sale cells have fenestrations (pores) that allow large molecules to flow into the extracellular space. Moreover, relatively nonselective transport may occur by pinocytosis in peripheral but not central nervous system capillaries. In contrast, in central nervous system capillaries, adjacent endothelial cells are tightly joined, preventing movement of compounds into the extracellular compartment of the central nervous system.

    The intercellular spaces between P.97 adjacent endothelial cells are leaky, moreover. The blood-brain barrier is thought to result from two characteristics of endothelial cells in the capillaries of the brain and spinal cord. There is little transcellular movement of compounds from intravascular to extracellular compartments in the central nervous system because the endothelial cells lack the required transport mechanisms, second.

    This permeability barrier protects the brain from neuroactive compounds in the blood as well as rapid changes in the ionic constituents of the blood that can affect neuronal excitability.

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