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    And evidence that opiates act at the dopamine cell bodies or dopamine synapse, data generated to support this theory at the time included evidence that amphetamine and cocaine act directly in equivalent viagra feminin the dopamine synapse in the terminal areas of the mesolimbic dopamine system. Alcohol, barbiturates, and benzodiazepines were speculated to act via a naloxone-reversible inhibition of noradrenergic function, which disinhibited rather than directly excited the dopamine reward link (Fig. Rather, most references to specific dopamine pathways in the discussion were to the ventral tegmentum or the tegmentalstriatal projections (Wise, 1976). Later discussions came to focus on the mesolimbic component per se.