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    Lesion of the Subthalamic Region Produces Hemiballism Ventral to the thalamus is the subthalamic region, which consists of a disparate collection of nuclei. Researchers know that the subthalamic nucleus is somatotopically organized, by examining patients who have experienced small vascular accidents in this area. Substance P is contained within the terminals of striatal neurons of the direct path and, therefore, is in greater abundance in the internal segment of the globus pallidus. Enkephalin is in striatal neurons of the indirect path and is restricted largely to the external segment of the globus pallidus, by contrast.

    The inset shows the plane of section. Two major nuclei in this poorly understood brain region are the subthalamic nucleus and zona incerta. Characterized by ballistic movements of the contralateral limbs, a lesion of the subthalamic nucleus produces hemiballism. The neuropeptide content of the internal segment of the globus pallidus is different from that of the external segment , p.373 Although GABA is present in both structures.

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