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    No commercially available vaccines comprar cialis online en españa exist for the prevention of hepatitis E, at present. 27. Should patients with chronic liver disease be immunized against hepatitis A and hepatitis B?. Recent studies demonstrated that recombinant hepatitis E vaccine suitable for clinical evaluation was highly immunogenic and efficacious in preventing hepatitis E and even infection in rhesus monkeys following intravenous challenge with three different genotypes of HEV. A 46-kDa recombinant HEV-derived ORF4 protein has been used to vaccinate rhesus monkeys against different strains of hepatitis E virus.

    Two doses of vaccine were essential for optimal protection. The titers of anti-HEV that were protective in this study were quantified against a World Health Organization standard. The results of this preclinical trial of a candidate hepatitis E vaccine strongly suggest that it will be highly efficacious for preventing hepatitis E in the field trial of this vaccine that is currently in progress in Nepal (an endemic setting). Several studies for the development of an effective vaccine against hepatitis E are in progress, however.

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