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    Such types of differential responses have been shown for cocaine, amphetamine, and heroin (Piazza and Le Moal, 1996. The differences are hypothesized to reflect differential reactivity of neurotransmitters (Fig. The difference between animals can be studied further by dividing the population in two or by the median , or by comparing the lowest and highest interquartiles to maximize the phenotypic differences (Ambrosio et al., 1992. Although the importance of individual differences in humans is well accepted in clinical practice, it has generally been neglected in animal studies.

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