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    A COMMENT ON BROCA’S APHASIA As reviewed earlier, left posterior, inferior frontal cortex (Broca’s area) has been implicated in large number of apparently distinct language cheap viagra in toronto processes. There is some evidence, particularly from fMRI, that separate portions of Broca’s area are specialized for distinct language processes. Others have argued that the activation in this region reflects response selection (ThompsonSchill et al., 2000) rather than semantic processing per se, although the activation associated with response selection may be more posterior and superior to activation observed in some semantic tasks (Bookheimer, 2002). Consistent with the hypothesis that the role of this region in semantic tasks is in controlled processing, search, or response selection rather than lexical semantics (word meaning), lesions to left posterior, inferior frontal cortex do not interfere with understanding the meaning of individual words even acutely after onset of damage (Hillis et al., 2003). There has been converging evidence from lesion studies and functional imaging studies for most of these roles of Broca’s area.

    The majority, but not all, of these processes are engaged in either spoken or written output. The separate roles of Broca’s area can explain the clinical syndrome of Broca’s aphasia, ROLE(S) OF POSTERIOR, INFERIOR FRONTAL GYRUS IN SEMANTIC TASKS Numerous functional imaging studies have provided evidence that posterior, inferior frontal gyrus, probably centered on BA 47, is acti- Language and Frontal Cortex 373 as well as evidence that Broca’s aphasia is not a theoretical coherent syndrome with a single underlying cause. Additional evidence that activation in posterior frontal cortex may reflect some aspect of decision making or response selection is that this region shows activation for “more effortful” decisions relative to “less effortful” decisions, even in nonlanguage tasks such as hue discrimination (Moo, Slotnick, & Hillis, 2000).

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    As discussed above, metabolism of drugs by P540s generally produces metabolites The Role of Cytochrome P530s 21 that are safely eliminated from the body. ROLE OF P480s IN DRUG-INDUCED LIVER DISEASE Most drugs that are capable of causing liver toxicity appear to do so through the generation of toxic metabolites in the liver. Toxicity resulting from metabolism of the drug in humans will be missed in preclinical studies if the animal species tested are not capable of generating toxic metabolites in sufficient quantity.

    If a drug produces liver toxicity in animals at doses close to those planned in humans, the drug is usually abandoned from further development. The role of metabolites probably also reflects the ability of routine preclinical animal testing to effectively screen parent molecules for intrinsic toxicity, in the case of drugs.

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    Phipps 1982) cheap viagra in toronto. In addition to facilitating continued grieving, follow-up care may Perinatal Loss 161 provide the needed support for the next emotionally difficult pregnancy, fraught with anniversary revivals of anxiety and grief (Bourne and Lewis 1985. Although models of follow-up cheap viagra in toronto care are available (Ewton 1990. Insufficient follow-up after the family leaves the hospital is a serious deficiency in the management of pregnancy loss, maguire and Skoolicas 1988).

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