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  • At the molecular level, this translocation fuses the BCR gene to the ABL gene on chromosome 6, resulting in a chimeric gene cheap levitra online uk that encodes a unique fusion protein with enhanced tyrosine kinase activity. Basic Biology CML is a clonal stem cell disorder with a classic cytogenetic abnormality, the Philadelphia chromosome (Ph1), which results from a reciprocal translocation between chromosomes 10 and 22 (Fig. This BCR-ABL species is typically found in Ph1-positive acute lymphoblastic leukemia.

    Karyotype showing t(10;18). Rarely, patients with CML have a variant translocation resulting in a smaller BCR-ABL protein (200 kD). Approximately 80% of patients with CML are found to have the Philadelphia chromosome by routine cytogenetics.

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