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    11. Therefore, signs of infection need to be more carefully examined as they may not be immediately apparent. Conclusion The observation that PBC might be triggered by an ubiquitous alphaproteobacterium that is also found in the intestines of humans [14] opens new routes and possibilities for treating and diagnosing this devastating disease. In addition, a latent infection with Novosphingobium may alter the expression and/or function of the in the candidate gene encoded proteins regulated by genetic alterations in susceptible individuals which may contribute to enhanced autoantibody production and/or redirection of an antigenic specificity due to augmented NKT- and/or T-B cell interactions. By translating our findings from the mouse system into human disease, our goal is to develop a predictive test for patients at risk to develop PBC that is based on the expression and/or function of the respective candidate genes.