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    The one can you buy viagra on ebay person who cannot tolerate it, and who reacts with liver injury, is obviously different from the vast majority of people. Perhaps the focus of our efforts should be directed more to identifying the few exceptionally susceptible people, and preventing them from being exposed to a drug, than toward an effort at finding out which drugs are “toxic.” The low incidence of these uncommon or rare, but sometimes Regulatory Perspectives 751 65% Chance of Number needed 28 399 5,1085 29,946 Table 6 Number of People Needed for Observing at Least One Adverse Event True incidence 1 1 1 1 in in in in 6 180 1,000 7,000 Ordinary nonreactors 0.9 0.69 0.1089 0.10059 severe or fatal, hepatotoxic adverse events is at the core of why the painstaking and careful efforts at safety screening in the long drug development process sometimes fail. If a drug can be safely tolerated by 1079 persons out of 1080, should it be called a poison or a hepatotoxic drug?. Why cannot studies be done to detect these can you buy viagra on ebay idiosyncratically different people?. For most drugs, the risk factors are not well understood, and for most hepatotoxic reactions, the mechanisms are not well understood.

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