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    Normalization of the peripheral blood counts was observed in 85% of patients. Virtually all imatinib-treated patients who achieved a major cytogenetic response with imatinib did so within the first year of treatment. A randomized trial of imatinib vs IFN-α plus cytarabine (standard therapy at the time) for newly diagnosed CML patients demonstrated markedly superior results for imatinib, with 55% of patients achieving a major cytogenetic response and 64% a complete cytogenetic response at 1 yr compared with 19% and 8%, respectively, for IFN-α plus cytarabine.

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