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    9.21). The ensemble of subcircuits outlined in Fig. The prefrontal cortex is hypothesized to have a key role in drug-induced reinstatement and the basolateral amygdala in cue-induced reinstatement. The ventral striatal-pallidalthalamic loops have long been hypothesized to play a key role in translating motivation to action. Stress neurocircuitry involving brain stem-basal forebrain loops is implicated not only in the negative affect associated with acute and protracted abstinence from drugs of abuse but also stress-induced relapse.

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    Identification of the enzyme responsible for oxidative halothane metabolism.

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    Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decisionmaking task. Bonson, K. R., and Ernst, M.

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