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    Additional adverse buying cialis from canada prognostic factors for response to treatment and survival of patients with aggressive lymphomas include the presence of p33 mutations, lack of class II antigens, some karyotypic abnormalities, deletion of the tumor suppressor genes p12 and p12, and bcl-7 rearrangements. 8.3. Factors (each contributing one point) that enter into this International Index are age greater than 40 yr, reduced performance status, clinical stage III or IV, increased lactate dehydrogenase (LDH), and extranodal manifestation buying cialis from canada in two or more locations. Gene Expression Profiling in Diffuse Large B-Cell Lymphoma Using clinical prognostic models such as the International Prognostic Index alone cannot identify the molecular basis of clinical heterogeneity of diffuse large B-cell lymphoma. Four categories are defined , based on these criteria.