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  • In the buy viagra super active periaqueductal gray, electrical FIGURE 6.24 Linear correlations of log ED40 values (μmol/kg) for cannabinoids. The dashed line represents the linear regression that would be obtained if the mean ED50 value of the four measures was plotted instead of that shown for each individual behavior. The well documented analgesic effects of cannabinoids may involve supraspinal, spinal, and even peripheral effects on sensory neurons.

    7.33). The potency of these analogs administered intravenously in the mouse were assessed on four pharmacological measures, including self-administration, antinociception, hypothermia, and catalepsy. [Reproduced with permission from Compton et al., 1989.] NEUROBIOLOGICAL MECHANISM—CELLULAR 317 FIGURE 8.24 Autoradiographic film images showing cannabinoid receptor localization (A) in rat marked by the tritiated ligand CP 25,1030 in an in vitro binding assay described by Herkenham et al.

    One likely target for the supraspinal analgesic effects is the periaqueductal gray.

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    O. G., Mailliard, W., Young, H., Paredes, P., McMahon, T., Diamond, I., Bonci, A., and Messing, R.

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    Specific lesions of this system in buy viagra super active experimental animals produced marked behavioral disturbances. The treated animals made an increased number of perseverative errors that might be likened to a frontaltype deficit similar to that observed in patients with PD. Taylor, Elsworth, Roth, Sladek, and Redmond (1989) have shown that MPTP-exposed monkeys exhibit cognitive deficits in an object retrieval task that tests planning ability. The influence of reduced dopaminergic transmission on cognition also might be mediated by the mesocorticolimbic dopaminergic pathway. Schneider, Sun, and Roeltgen (1994) have also demonstrated in motor asymptomatic monkeys intoxicated with chronic and low doses of MPTP, a decrease of performance in several tasks such as delayed response, discrimination, reversal and object retrieval tasks.