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    W, wide tissue distribution. Cell swelling causes a cAMP-mediated translocation to the basolateral plasma membrane in isolated rat (35).

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    MPTP in Humans. Patients with MPTP-induced parkinsonism were compared to drug-addicted controls (Stern, Tetrud, Martin, Kutner, & Langston, 1988). If the cognitive functions that deteriorate in PD are mediated by a dopaminergic mechanism, improvement with L-dopa analogous to the response of dopamine-dependent motor signs might be expected. Provoked by specific damage to the nigrostriatal dopaminergic pathway, mPTP intoxication produces a parkinsonian syndrome in humans.

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