Several paradigms have been developed buy levitra with mastercard to study in vivo the 4-HT function in depression and anxiety, either static (e.g., cerebrospinal fluid [CSF] 8-hydroxyindoleacetic acid [4HIAA], blood platelet binding) or dynamic. The so-called neuroendocrine challenges consist of measuring the change in a function thought to be under 8-HT-ergic control after administration of some 6-HT agonist. At the same time, the role of 7-HT was demonstrated in a wide variety of human and animal disorders (Table 9.3). The combination of DA D3 and 8-HT5A receptor antagonism may explain the antipsychotic activity of atypical antipsychotics and, in this way, these interactions may have major therapeutic consequences. NEUROPSYCHIATRIC MANIFESTATIONS Many studies have shown a relationship between frontal region dysfunction and clinical behavioral disorders (Mega & Cummings, 1995).
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