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    Troglitazone Troglitazone, a thiazolidinedione agent that decreases hepatic glucose output and increases insulin-dependent glucose metabolism in skeletal muscle, has been withdrawn from clinical use because of hepatic toxicity. Two treated patients became clinically jaundiced during the trial. No deaths or instances of acute liver failure occurred and biochemical abnormalities seen during the trial returned to normal following drug withdrawal with no evidence of any residual problems.

    The hepatic injuries in patients who developed liver injury following release of troglitazone were predominantly hepatocellular. Several instances of acute liver failure leading to death or the need for liver transplantation occurred after the drug was approved in 1998 Clinicopathological Patterns 247 and was subsequently widely used.

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