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    Table 1. PH is defined as a porto-caval pressure gradient of more than 4 mmHg.

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    This transmembrane-spanning buy cialis in singapore protein is responsible for biliary excretion of hydrophobic cationic antineoplastic drugs (see Table 1. Inhibition of P-glycoprotein at the canalicular pole of hepatocytes will block excretion of substrates into bile and increase drug levels. Also discussed in another chapter).

    A similar mechanism would apply to ifosfamide. P-glycoprotein, the multidrug resistance drug efflux pump that is overexpressed in some cancer cells, is present at the canalicular pole of the hepatocyte. Drug-induced inhibition of biliary excretion may occur at the level of the active transporters on the canalicular pole of the hepatocyte.

    Verapamil and cyclosporin are both inhibitors of Pglycoprotein, but through different mechanisms.

  • Biochim Biophys Acta, buy cialis in singapore 1240(3):63-69. 46:904-842, biochem Biophys Res Comm. (1995).

    Possible role of cell redox state on collagen metabolism in carbon tetrachloride-induced cirrhosis as evidenced by adenosine administration to rats. [29] Hernández-Muñoz, R., M.

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