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  • Alzheimer again considered the presence of focal symptoms , noting, however, that they were difficult to analyze because of severe language deficits buy cheap generic levitra. A further peculiarity of the present case was the localization of the alterations. A few years later, Alzheimer described a second patient, Johann F, a 26-year-old man who first became “quiet and dull,” and then 1.5 years later developed symptoms of forgetfulness, getting lost, overeating, poor hygiene, and difficulty performing simple tasks. At autopsy, Alzheimer found an “evenly affected atrophic brain without macroscopic foci” and the deposition of cored plaques and intracellular fibrils (now buy cheap generic levitra known as neurofibrillary tangles). He discussed the distribution of neuropathology, at autopsy.

    Original German in Note 1) He considered the clinical presentation atypical because it did not resemble other, known clinical patterns with an onset in later middle age. Even if we were dealing with a diffuse disease of the cortex alone, the parietal and temporal lobes bilaterally were unmistakably especially affected and much more so than the frontal brain.

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