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    A ROI analysis of PET in 17 patients with the clinical diagnosis of FTD showed reduced glucose metabolism relative to patients with AD in orbital, middle and superior frontal, anterior temporal, anterior cingulate, and hippocampal regions bilaterally, as well as in left inferior frontal cortex. Whereas patients with semantic dementia showed progressive atrophy in a unilateral anterior ROI, patients with FTD who have a social disorder showed more rapid longitudinal change in anterior ROIs bilaterally. Moreover, given the great variability of cortical volume loss in older populations, longitudinal change provides a more valid picture of the specific brain regions that are becoming systematically atrophic more rapidly than would be expected in healthy aging. Another way to improve the validity of imaging in FTD is through longitudinal studies.

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