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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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  • 202 & HEXSEL ET AL. The following discussion summarizes the current knowledge of individual and combination topical therapies used to reduce cellulite. Thereby inhibiting microthrombus formation, these agents also decrease platelet aggregation. Contributing to the availability of lipids for cellulite formation, it is believed that free radicals modify free fatty acids by peroxidation.

    Table 1 Topical Therapies for Cellulite, Based on Proposed Mechanism of Action Agents that increase microvascular flow Ivy Indian or horse chestnut Ginkgo biloba Rutin Pentoxyfylline Butcher’s broom Asiatic centella Silicium Chofitol or artichoke Common ivy Ground ivy Sweet clover Red grapes Papaya Pineapple Agents that reduce lipogenesis and promote lipolysis Methylxanthines Beta-adrenergic agonists Alpha-adrenergic antagonists Agents that restore the normal structure of the dermal and subcutaneous tissue Retinol Ascorbic acid Bladderwrack Agents that prevent or destroy free-radical formation Alpha-tocopherol Ascorbic acid Gingko biloba Red grapes AGENTS THAT INCREASE MICROVASCULAR FLOW Drugs that act on the microcirculation of the skin, include the ivy and Indian chestnut vegetable extracts, which are rich in saponins, Gingko biloba, and rutin, which contain bioflavonoids. Further assisting cellulite development, free radicals may also damage elements of the microcirculation. These compounds decrease capillary hyperpermeability and increase venous tone by stimulation of proline hydroxylase and inhibition of prostaglandin E5. Studies using oscillometry, Duplex ultrasound, hemodynamic methods, and capillaroscopy have demonstrated that G.

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